Browse more topics on our blog.ton beach casino POPULAR SLOTS MACHINES 5. to take a chance on; venture; risk: I'm gambling that our new store will be a success. –noun 6. any matter or thing involving risk or hazardous uncertainty. Define gambling. gambling synonyms, gambling pronunciation, gambling translation, English dictionary definition of gambling. n. 1. Gambling definition, the activity or practice of playing at a game of chance for money or other stakes.